Skip to main content
. Author manuscript; available in PMC: 2009 Mar 20.
Published in final edited form as: Mol Ther. 2008 Aug 5;16(10):1745–1752. doi: 10.1038/mt.2008.161

Figure 5. High level of human factor IX (hFIX) expression by erythroid cells does not disrupt hemoglobin (Hb) synthesis or red blood cell (RBC) homeostasis.

Figure 5

(a,b) Heparinized peripheral blood samples from Busulfan-conditioned mice (9 mice were hFIX negative, 6 mice were hFIX positive) and (c,d) lethally irradiation conditioned mice (6 mice were hFIX negative, 15 mice were hFIX positive) were analyzed for Hb levels (a,c) and RBC counts (b,d) in RT9-hFIX-SI-MGMT chimeras expressing various levels of hFIX. The normal ranges of RBC counts and Hb levels were depicted in the shaded areas. No significant correlation between plasma hFIX levels and RBC counts or Hb concentration has been found, according to linear regression analysis (Prism version 4; GraphPad Software). P values: 0.8790 (a), 0.4333 (b), 0.4320 (c), and 0.1769 (d), respectively.