Figure 6. Ectopically expressed human factor IX (hFIX) does not alter the morphological phenotype of erythrocytes.
Confocal microscopy of peripheral blood erythrocytes from a (a) control C57BL/6, FIX-/- mouse and a C57BL/6, FIX-/- mouse engrafted with bone marrow cells from a (b) primary RT9-hFIX-SI-MGMT chimera. Cells were double stained by Ter119-Alexa and hFIX-FITC. Yellow arrows in b indicate typical hFIX-positive cells. MGMT, methylguanine methyltransferase.