Table 2 Effects of glyceryl trinitrate 1.25 mg/day through transdermal patch and rehabilitation versus rehabilitation alone on tennis elbow (adapted from Paoloni et al19).
| Week | Active | Placebo | p Value |
|---|---|---|---|
| Pain with activity—all patients | |||
| (n = 35) | (n = 39) | ||
| 2 | 2.1 | 2.3 | 0.31 |
| 6 | 1.8 | 1.9 | 0.57 |
| 12 | 1.5 | 1.6 | 0.61 |
| 24 | 1.3 | 1.5 | 0.56 |
| Pain with activity—bilateral patients excluded | |||
| (n = 31) | (n = 37) | ||
| 2 | 2.1 | 2.4 | 0.11 |
| 6 | 1.8 | 1.9 | 0.57 |
| 12 | 1.5 | 1.6 | 0.72 |
| 24 | 1.3 | 1.5 | 0.43 |
| Tenderness—by elbow | |||
| (n = 39) | (n = 41) | ||
| 2 | 1.0 | 1.1 | 0.25 |
| 6 | 0.7 | 1.1 | 0.014 |
| 12 | 0.7 | 1.1 | 0.006 |
| 24 | 0.5 | 1.0 | 0.014 |
| Tenderness—bilateral data averaged | |||
| (n = 35) | (n = 40) | ||
| 2 | 1.0 | 1.2 | 0.08 |
| 6 | 0.6 | 1.1 | 0.010 |
| 12 | 0.6 | 1.1 | 0.003 |
| 24 | 0.5 | 1.0 | 0.008 |
| Tenderness—bilateral patients excluded | |||
| (n = 31) | (n = 38) | ||
| 2 | 0.9 | 1.2 | 0.037 |
| 6 | 0.8 | 1.3 | 0.008 |
| 12 | 0.8 | 1.3 | 0.002 |
| 24 | 0.6 | 1.1 | 0.008 |
| Change from baseline in total work—by elbow | |||
| (n = 39) | (n = 41) | ||
| 2 | 8.9 | −1.8 | 0.048 |
| 6 | 21.6 | 5.6 | 0.007 |
| 12 | 23.0 | 6.5 | 0.019 |
| 24 | 35.9 | 15.4 | 0.019 |
| Change from baseline in total work—all patients—bilateral data averaged | |||
| (n = 35) | (n = 39) | ||
| 2 | 9.8 | −2.0 | 0.036 |
| 6 | 23.1 | 6.5 | 0.007 |
| 12 | 23.2 | 7.3 | 0.027 |
| 24 | 38.5 | 17.1 | 0.020 |
| Change from baseline in total work—bilateral patients excluded | |||
| (n = 31) | (n = 37) | ||
| 2 | 11.0 | −2.4 | 0.028 |
| 6 | 25.0 | 7.4 | 0.007 |
| 12 | 23.4 | 8.0 | 0.044 |
| 24 | 41.9 | 18.9 | 0.019 |
| Pain at night—all patients | |||
| (n = 35) | (n = 39) | ||
| 2 | 1.2 | 1.4 | 0.28 |
| 6 | 0.9 | 1.2 | 0.20 |
| 12 | 0.9 | 1.1 | 0.33 |
| 24 | 0.7 | 0.8 | 0.44 |
| Pain at night—bilateral patients excluded | |||
| (n = 31) | (n = 37) | ||
| 2 | 1.1 | 1.4 | 0.13 |
| 6 | 0.9 | 1.2 | 0.24 |
| 12 | 0.9 | 1.1 | 0.38 |
| 24 | 0.6 | 0.8 | 0.39 |
| Pain at rest—all patients | |||
| (n = 35) | (n = 39) | ||
| 2 | 1.1 | 1.2 | 0.84 |
| 6 | 0.8 | 1.0 | 0.32 |
| 12 | 0.9 | 1.0 | 0.54 |
| 24 | 0.9 | 1.0 | 0.66 |
| Pain at rest—bilateral patients excluded | |||
| (n = 31) | (n = 37) | ||
| 2 | 1.0 | 1.1 | 0.56 |
| 6 | 0.8 | 1.1 | 0.27 |
| 12 | 0.9 | 1.0 | 0.69 |
| 24 | 0.9 | 1.0 | 0.67 |
| Change from baseline in peak force—by elbow | |||
| (n = 39) | (n = 41) | ||
| 2 | 1.3 | 0.0 | 0.06 |
| 6 | 2.5 | 0.8 | 0.016 |
| 12 | 2.6 | 0.6 | 0.020 |
| 24 | 3.4 | 1.4 | 0.025 |
| Change from baseline in peak force—all patients—bilateral data averaged | |||
| (n = 35) | (n = 39) | ||
| 2 | 1.4 | −0.01 | 0.041 |
| 6 | 2.6 | 0.9 | 0.015 |
| 12 | 2.6 | 0.7 | 0.024 |
| 24 | 3.7 | 1.6 | 0.024 |
| Change from baseline in peak force—bilateral patients excluded | |||
| (n = 31) | (n = 37) | ||
| 2 | 1.6 | −0.1 | 0.027 |
| 6 | 2.8 | 1.0 | 0.016 |
| 12 | 2.6 | 0.8 | 0.036 |
| 24 | 4.1 | 1.8 | 0.021 |
All results are adjusted for the baseline (week 0) value.