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. 2007 Apr;41(4):227–231. doi: 10.1136/bjsm.2006.034447

Table 4 Effects of glyceryl trinitrate 1.25 mg/day through transdermal patch and rehabilitation versus rehabilitation alone in patients with supraspinatus tendinopathy (adapted from Paoloni et al20).

Week Active Placebo p Value
Pain with activity—by shoulder
(n = 28) (n = 28)
2 2.2 2.1 0.80
6 1.9 2.1 0.34
12 1.6 1.9 0.36
24 1.0 1.8 0.006
Pain at rest—by shoulder
(n = 27) (n = 28)
2 1.7 1.9 0.47
6 1.5 1.6 0.68
12 1.1 1.4 0.19
24 0.7 1.2 0.09
Pain at night—by shoulder
(n = 27) (n = 27)
2 1.4 1.6 0.61
6 1.4 1.5 0.72
12 1.0 1.5 0.09
24 0.8 1.4 0.031
Tenderness—by shoulder
(n = 27) (n = 28)
2 0.1 0.4 0.012
6 0.2 0.5 0.017
12 0.2 0.4 0.18
24 0.2 0.2 0.60
Change from baseline in abduction range of motion—by shoulder
(n = 27) (n = 29)
2 7.7 1.5 0.15
6 7.8 2.0 0.29
12 16.3 1.2 0.020
24 26.6 8.7 0.004
Change from baseline in adduction power—by shoulder
(n = 27) (n = 28)
2 5.6 1.3 0.24
6 7.7 −0.6 0.08
12 11.9 0.4 0.023
24 9.9 1.6 0.11
Change from baseline in external rotation power—by shoulder
(n = 27) (n = 28)
2 4.7 0.5 0.17
6 7.4 0.8 0.11
12 11.5 0.5 0.023
24 13.4 0.3 0.013
Change from baseline in external rotation range of motion—by shoulder
(n = 27) (n = 27)
2 1.9 6.7 0.13
6 4.7 1.9 0.45
12 7.7 3.3 0.26
24 13.2 8.5 0.17
Change from baseline in forward flexion—by shoulder
(n = 36) (n = 41)
2 7.8 0.8 0.11
6 6.5 −2.3 0.09
12 13.4 −2.2 0.019
24 20.3 6.3 0.027
Impingement external rotation (% with 0)—by shoulder
(n = 27) (n = 28)
2 40.7 32.1 0.51
6 40.7 32.1 0.57
12 70.4 57.1 0.36
24 70.4 50.0 0.15
Impingement internal rotation (% with 0)—by shoulder
(n = 27) (n = 28)
2 33.3 10.7 0.059
6 48.2 17.9 0.040
12 51.9 32.1 0.15
24 74.1 39.3 0.018
Change from baseline in internal rotation power—by shoulder
(n = 27) (n = 28)
2 4.9 −0.9 0.14
6 10.8 2.0 0.055
12 11.0 −1.5 0.029
24 13.9 1.1 0.018
Change from baseline in internal rotation range of motion—by shoulder
(n = 27) (n = 28)
2 −2.3 0.5 0.37
6 −4.3 −1.0 0.22
12 −5.0 0.6 0.15
24 −8.1 −0.3 0.32
Change from baseline in subscapularis power—by shoulder
(n = 27) (n = 28)
2 9.0 0.9 0.009
6 9.2 5.4 0.24
12 14.0 5.8 0.045
24 15.7 6.6 0.018
Change from baseline in supraspinatus power—by shoulder
(n = 27) (n = 28)
2 3.6 −1.5 0.10
6 11.0 0.7 0.009
12 15.4 2.0 0.010
24 16.2 2.9 0.007