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. 2009 Mar 27;284(13):8329–8336. doi: 10.1074/jbc.M807387200

FIGURE 4.

FIGURE 4.

The actin motor protein, myosin, is involved in D4 reduction of GABAAR currents. A, plot of normalized peak GABAAR current as a function of time and PD168077 (30 μm) application in neurons dialyzed with or without the myosin peptide (25 μm). Inset, representative current traces (at time points denoted by #). Scale bar, 200 pA, 1 s. B, cumulative data (mean ± S.E.) showing the percentage of reduction of GABAAR current by PD168077 in a sample of neurons dialyzed with or without the myosin peptide. *, p < 0.005, ANOVA. C, cumulative plots of the distribution of mIPSC amplitudes before (control) and after PD168077 (30 μm) application in cultured PFC neurons dialyzed with or without the myosin peptide (25 μm). Inset, representative mIPSC traces. Scale bar, 50 pA, 1 s. D, cumulative data (mean ± S.E.) showing the percentage of reduction of mIPSC amplitudes by PD168077 in the absence and presence of the myosin peptide. E, plot of normalized peak evoked IPSC as a function of time and PD168077 application in PFC neurons dialyzed with the myosin peptide (25 μm) or a scrambled control peptide (25 μm). F, cumulative data (means ± S.E.) showing the percentage of reduction of evoked IPSC amplitude by PD168077 in the absence and presence of the myosin peptide. *, p < 0.005, ANOVA. PD, PD168077; ctl, control; pep., peptide.