FIGURE 5.

Effects of intracellular Ca²⁺, oxidation, and local anesthetics on action potential (AP) conduction using the Luo-Rudy model. Action potentials from the middle of the one-dimensional fiber for the different conditions are overlaid to illustrate changes in action potential duration and upstroke velocity. The inset shows the AP upstroke at greater magnification. The conduction velocities computed from the fiber in high [Ca²⁺](D), high [Ca²⁺](D) plus oxidant, low [Ca²⁺](D) plus oxidant and high [Ca²⁺](D) plus oxidant plus LA were 67, 64, 0, and 4 cm/s, respectively. The following values for the V_½ were used to generate the data: -71.3 mV in high [Ca²⁺]_i; -75.2 mV in high [Ca²⁺]_i plus t-BHP; -86.7 mV in low [Ca²⁺]_i plus t-BHP; -80.3 mV in high [Ca²⁺]_i plus t-BHP plus LA.