TABLE 1.

Effects of [Ca²⁺]_i and lidocaine on the V_½ of steady-state inactivation for Na_V 1.5

WT, A1924T and FIF/AAA. All data represent the mean ± S.E. The V_½ for WT, A1924T, and FIF/AAA in high [Ca²⁺]_i were not different.

	WT	A1924T	FIF/AAA
1 μm Ca2+	−71.3 ± 0.9 mV	−74.7 ± 1.9 mV	−73.7 ± 1.0 mV
1 μm Ca2+ + lidocaine	−79.6 ± 1.7 mVa	−75.4 ± 1.4 mVb	−74.1 ± 0.6 mVb
20 mm BAPTA	−79.6 ± 1.0 mVc	−87.4 ± 1.2 mVc,d	−85.9 ± 0.9 mVc,d
20 mm BAPTA + lidocaine	−83.0 ± 0.8 mVa,c	−85.5 ± 1.5 mVb,c

^ap < 0.05 versus same condition without lidocaine.

^bp = NS versus same condition without lidocaine.

^cp < 0.05 versus same condition as in 1 μm Ca²⁺.

^dp < 0.05 versus WT + 20 mm BAPTA.