Table 3.
Association between peripartum migraine and vascular diagnoses or cardiovascular risk factors
| Vascular diagnosis or risk factor | ICD-9 codes | Migraine rate per 100 000* | Odds ratio (95% CI) | P value |
|---|---|---|---|---|
| All strokes | 430, 431, 434, 436, 325, 674.0 | 2839 | 15.8 (11.1 to 22.5) | <0.001 |
| Ischaemic stroke | 434, 436 | 5364 | 30.7 (17.4 to 34.1) | <0.001 |
| Intracerebral haemorrhage | 431 | 1653 | 9.1 (3.0 to 27.8) | <0.001 |
| Cerebral venous thrombosis | 325 | 0 | – | – |
| Subarachnoid haemorrhage | 430 | 615 | 3.4 (0.5 to 24.1) | 0.23 |
| Pregnancy related cerebrovascular event | 674 | 2546 | 14.1 (8.7 to 23.1) | <0.001 |
| Myocardial infarction | 410 | 1771 | 4.9 (1.7 to 14.2) | <0.001 |
| Heart disease | 648.5, 648.6 | 410 | 2.1 (1.8 to 2.6) | <0.001 |
| Pulmonary embolus | 673.2, 415.1 | 760 | 3.1 (1.7 to 5.6) | <0.001 |
| Deep venous thrombosis | 671.3, 451.1, 451.2 | 515 | 2.4 (1.3 to 4.2) | <0.001 |
| Thrombophilia | 282.62, 282.42, 282.64 | 781 | 3.6 (2.1 to 6.1) | <0.001 |
| Hypertension | 401-405 | 740 | 3.6 (3.1 to 4.2) | <0.001 |
| Cardiomyopathy | 425 | 636 | 2.2 (1.3 to 3.7) | <0.001 |
| Diabetes | 648.0, 250 | 482 | 2.3 (1.9 to 2.7) | <0.001 |
| Smoking | 305.1, V15.82 | 489 | 2.7 (2.4 to 3.1) | <0.001 |
ICD-9= international classification of diseases, 9th revision.
*Migraine rate per 100 000 discharges for each vascular diagnosis or risk factor.