Figure 3.

Effect of caudal brainstem leptin receptor stimulation (1 μl, 4th v delivery) on (A) core temperature, (B) HR, and (C) spontaneous activity in HF-fed rats. Line graphs represent across-rat average parameter measurements through the 8-h recording period. The bracketed time period on the line graph x-axis indicates the periods used in the histograms. The histograms provide 6-h postinjection averages ± sem for each parameter at each dose. *, P < 0.05 (n = 15). ICV, Intracerebroventricular.