Figure 3.

Inability of PAM^+/− mice to regulate body temperature is reversed by dietary copper. Core body temperatures of PAM^+/− (n = 8, 9) and WT (n = 9, 11) mice with and without dietary copper supplementation (Cu²⁺ Suppl.; n/group = 8–11) were monitored every 40 min in response to a 120-min exposure to 4 C; error bars, sem. An ANOVA of this mixed design revealed significant main effects of both genotype and copper supplementation (P < 0.0005) and a significant interaction between genotype and copper supplementation (P < 0.0005). Only the PAM^+/− mice showed a significant change in their body temperature in response to supplementation of dietary copper. Asterisk, See Statistical analysis for P-values.