Table 2.
Medial temporal lobe tissue composition and adjusted metabolite concentration
| Adjusted Group Differences | |||||
|---|---|---|---|---|---|
| Metabolites | Depressed (N = 14) |
Nondepressed (N = 12) |
F value | Df | P value |
| Left Medial Temporal Lobe | |||||
| NAA | 10.69 (1.43) | 9.61 (1.11) | 5.25 | 1 | 0.035 |
| Cho | 2.88 (0.49) | 2.57 (0.32) | 3.91 | 1 | 0.065 |
| Cre | 8.40 (1.07) | 8.05 (0.87) | 0.91 | 1 | 0.353 |
| mI | 7.16 (1.65) | 6.11 (1.64) | 4.66 | 1 | 0.045 |
| Glx | 13.79 (1.73) | 12.63 (2.54) | 1.69 | 1 | 0.212 |
| Glu |
8.53 (0.96) | 8.01 (1.51) | 0.55 | 1 | 0.469 |
| CSF (%) | 7.4 (19.2) | 3.1 (3.5) | 0.50 | 1 | 0.488 |
| Gray Matter (%) | 67.1 (17.3) | 74.1 (11.1) | 1.12 | 1 | 0.305 |
| White Matter (%) | 25.9 (15.4) | 23.2 (8.6) | 0.24 | 1 | 0.631 |
|
| |||||
| Right Medial Temporal Lobe | |||||
| NAA | 10.37 (1.35) | 10.05 (0.76) | 0.40 | 1 | 0.533 |
| Cho | 2.62 (0.43) | 2.64 (0.41) | 0.06 | 1 | 0.809 |
| Cre | 8.45 (1.26) | 8.18 (1.02) | 0.47 | 1 | 0.502 |
| mI | 6.64 (1.19) | 6.81 (1.44) | 0.19 | 1 | 0.669 |
| Glx | 13.44 (1.73) | 14.41 (2.48) | 1.06 | 1 | 0.315 |
| Glu |
8.06 (1.52) | 8.97 (1.61) | 1.70 | 1 | 0.209 |
| CSF (%) | 2.4 (2.5) | 8.1 (17.8) | 0.97 | 1 | 0.337 |
| Gray Matter (%) | 69.8 (8.8) | 61.1 (13.2) | 3.14 | 1 | 0.092 |
| White Matter (%) | 27.8 (9.3) | 30.8 (14.2) | 0.33 | 1 | 0.573 |
Table presents absolute concentrations of meatabolites in mM, adjusted for presence of CSF and gray/white matter ratio, presented as mean (SD). Tissue composition displayed as the mean (SD) percent of the voxel filled by that type. Group comparisons performed using ANCOVA, including age and sex as covariates; the models had 25 degrees of freedom.
Key: NAA = N-Acetyl aspartate; Cho = choline; Cre = creatine; mI = myo-Inositol; Glx = glutamate + glutamine; Glu = glutamate.