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. Author manuscript; available in PMC: 2009 Mar 22.
Published in final edited form as: Circ Res. 2008 Feb 7;102(6):669–676. doi: 10.1161/CIRCRESAHA.107.165845

Figure 5.

Figure 5

Expression of Sphk1 in liver restores plasma S1P in Sphk1−/− mice. A, Plasma S1P levels in wild-type and Sphk1−/− mice. B, Adenoviral transduction of Sphk1 into Sphk1−/− mice restored plasma S1P levels. **P<0.01. C through F, Immunohistochemistry of liver sections stained with an Sphk1 antibody (brown) and counterstained with hematoxylin: wild-type (C), Sphk1−/− (D), Sphk1−/−transduced with Sphk1 adenovirus (E), and Sphk1−/− transduced with GFP adenovirus (F). Note the strong expression of Sphk1 in sinusoidal endothelial cells of liver (E arrows).