TABLE 1.
Passive and active electrical properties of LS and TL bladder neurons from CYP-treated and control rats
| Property | Treatment | LS | TL |
|---|---|---|---|
| A. Current injection | |||
| RMP, mV | Control | −55.02 ± 2.1 | −47.78 ± 1.0* |
| CYP | −55.34 ± 1.6 | −49.61 ± 1.3 | |
| Spontaneous activity | Control | 0/23 (0%) | 0/23 (0%) |
| CYP | 11/31 (35%)† | 13/29 (45%)† | |
| Rheobase, pA | Control | 146.1 ± 14.5 | 95.7 ± 7.5* |
| CYP | 66.2 ± 6.2† | 50.6 ± 5.5† | |
| Rheobase, pA/pF | Control | 5.67 ± 0.7 | 2.54 ± 0.2* |
| CYP | 2.28 ± 0.3† | 1.14 ± 0.2† | |
| AP threshold, mV | Control | −24.5 ± 1.4 | −23.3 ± 0.7 |
| CYP | −30.1 ± 0.8† | −28.2 ± 1.0† | |
| AP amplitude, mV | Control | 87.9 ± 4.1 | 87.4 ± 2.1 |
| CYP | 93.4 ± 2.2 | 89.9 ± 3.0 | |
| AP duration, ms | Control | 3.1 ± 0.2 | 3.2 ± 0.2 |
| CYP | 4.2 ± 0.3† | 5.0 ± 0.6† | |
| Rheobase × 2 (APs) | Control | 5.0 ± 0.9 | 6.3 ± 0.6 |
| CYP | 10.7 ± 2.1† | 9.2 ± 0.7† | |
| B. ATP (100 μM) | |||
| Depolarization, mV | Control | 24.5 ± 1.5 | 6.2 ± 1.2* |
| CYP | 31.9 ± 1.5† | 14.1 ± 1.2† | |
| Number of APs | Control | 8.9 ± 0.7 | 3.7 ± 1.4* |
| CYP | 15.2 ± 2.1† | 13.5 ± 3.6† | |
| C. αβ-metATP (100 μM) | |||
| Depolarization, mV | Control | 15.3 ± 1.4 | 5.4 ± 1.1* |
| CYP | 25.6 ± 1.3† | 13.2 ± 1.2† | |
| Number of APs | Control | 5.2 ± 0.7 | 2.4 ± 1.3* |
| CYP | 12.9 ± 0.9† | 10.3 ± 1.4† | |
Values are means ± SE, or percentages.
*
P < 0.05 versus LS counterparts
†
P < 0.05 versus control (saline) treatment.