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. Author manuscript; available in PMC: 2009 Oct 28.
Published in final edited form as: J Am Coll Cardiol. 2008 Oct 28;52(18):1468–1481. doi: 10.1016/j.jacc.2008.07.047

Figure 3. Blood pressure response to environmental (cold) stress in twin pairs: Effect of CHGA common allelic variant C+87T in the 3’-UTR, as well as sex.

Figure 3

Provocation of efferent sympathetic outflow was undertaken in each subject by immersion of one hand in ice water (at 0°C) for one minute, with continuous blood pressure monitoring. Results are shown for final (post-cold) SBP, and analyzed by generalized estimating equations, establishing an exchangeable correlation matrix to take into account intra-twin-pair correlations.

Panel A: CHGA C+87T genotype effect on post-stress SBP; data are shown in all persons, as well as men and women separately. Genotype affected the trait (p=0.042), and there was no gene-by-sex interaction (p=0.159) on trait.

Panel B: Sex effect on post-stress SBP (p=0.009).