. Author manuscript; available in PMC: 2009 Oct 28.

Published in final edited form as: J Am Coll Cardiol. 2008 Oct 28;52(18):1468–1481. doi: 10.1016/j.jacc.2008.07.047

Table 1. CHGA haplotypes across the locus in subjects with extreme BP values in the population.

Characteristics of the individual variants. Base positions are numbered (−/+) with respect to the cap site (exon-1, or transcriptional start site).

Variant	Position to cap site (−/+)	Domain	Major allele (%)	Minor allele (%)	Hardy-Weinberg equilibrium
					χ²	p
G-462A	−462	Promoter	G (76.7%)	A (23.3%)	9.20	0.002
Glu246Asp	+8540	Coding, exon 6	Glu (92.0%)	Asp (8.0%)	0.76	0.384
Arg381Trp	+9610	Coding, exon 7	Arg (86.3%)	Trp (13.7%)	1.39	0.238
C+87T	+11825	3’-UTR, exon 8	C (73.5%)	T (26.5%)	0.260	0.610