Table 1. CHGA haplotypes across the locus in subjects with extreme BP values in the population.
Variant | Position to cap site (−/+) | Domain | Major allele (%) | Minor allele (%) | Hardy-Weinberg equilibrium | |
---|---|---|---|---|---|---|
χ2 | p | |||||
G-462A | −462 | Promoter | G (76.7%) | A (23.3%) | 9.20 | 0.002 |
Glu246Asp | +8540 | Coding, exon 6 | Glu (92.0%) | Asp (8.0%) | 0.76 | 0.384 |
Arg381Trp | +9610 | Coding, exon 7 | Arg (86.3%) | Trp (13.7%) | 1.39 | 0.238 |
C+87T | +11825 | 3’-UTR, exon 8 | C (73.5%) | T (26.5%) | 0.260 | 0.610 |