Table 2. Analysis of Association between HSPA1A Polymorphisms and Risk of CHD in a Chinese population.
Genotype | Cases | Controls | Crude OR (95% CI) | Adjusted OR (95% CI)* | ||
n | % | n | % | |||
+190G/C | ||||||
GG | 434 | 44.2 | 479 | 47.8 | 1.00 | 1.00 |
GC | 416 | 42.4 | 415 | 41.4 | 1.11(0.92–1.34) | 1.04(0.83–1.31) |
CC | 131 | 13.4 | 109 | 10.8 | 1.33(1.00–1.77)† | 1.56(1.10–2.20)‡ |
GC+CC | 547 | 55.8 | 524 | 52.2 | 1.15(0.97–1.38) | 1.13(0.91–1.40) |
−110A/C | ||||||
AA | 317 | 32.3 | 350 | 34.9 | 1.00 | 1.00 |
AC | 476 | 48.6 | 472 | 47.1 | 1.11(0.91–1.36) | 1.15(0.90–1.46) |
CC | 187 | 19.1 | 181 | 18.0 | 1.14(0.88–1.47) | 1.17(0.86–1.60) |
AC+CC | 663 | 67.7 | 653 | 65.1 | 1.12(0.93–1.35) | 1.14(0.91–1.43) |
Adjusted for age, sex, pack-year of smoking, drinking, activity, hypertension, DM and family history of CHD. Compared with GG genotype.
P = 0.052 and
P = 0.012, respectively.