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. 2009 Mar 31;4(3):e5070. doi: 10.1371/journal.pone.0005070

Figure 1. Amino acid sequences of 4E-BP proteins.

Figure 1

Sg4E-BP protein was predicted from the cDNA and aligned with the three human 4E-BPs, Ciona intestinalis 4E-BP, Drosophila melanogaster Thor, Aplysia californica 4E-BP and Nematostella vectensis 4E-BP. Accession numbers of human proteins are: 4E-BP1 (NP_004086), 4E-BP2 (Q13542), 4E-BP3 (NP_003723) on NCBI. The Accession number is NP_477295 for Drosophila melanogaster (NCBI), 299279 for Ciona intestinalis (http://genome.jgi-psf.org/Cioin2/) and SB_47700 for Nematostella vectensis (http://www.stellabase.org/). The Aplysia californica sequence 4E-BP was obtained from [44]. The four residues known to be phosphorylated on human 4E-BPs and conserved on sea urchin are indicated by stars. Identical and conserved amino acid residues are on black and grey background, respectively. The common eIF4E motif indicated by YxxxxLΦ (where x is any amino acid and Φ is an hydrophobic residue), the RAIP motif and the TOS (TOR signalling) site are denoted with a line above.