Figure 7. Comparison between predicted and measured variable values.

Measured values were obtained from the references listed. The ranges of predicted variable values shown in Figure 6 are redrawn as grey silhouettes; the experimental data is plotted as boxes. On the ordinate the box indicates the reported statistical errors; on the time axis the box width is arbitrarily set to 26–34 h for trophozoites, 36–46 h for schizonts, and 42–48 h for segmentors using the period assignations in the original papers. Data for uninfected cells is shown at time = 0, where available. Symbols indicate the source of the data, as follows: closed circles – Park et al. [40]; open and closed triangles – Elliott et al. [23],[38]; open diamonds – Krugliak et al. [12]; open stars – Zanner et al. [39]; open squares – Saliba et al. [33]; closed diamonds – Esposito et al. [41]. (A) Host cell water volume, relative to initial IRBC volume; (B) IRBC volume, relative to initial volume; (C) relative parasite volume; (D) host cell Hb content, in mmol(10¹³ cells)⁻¹; (E) Hb concentration in host cell water, mM. Data in (B) and (E) were modified from the original references to fit the units used in the model (E) or to provide plausible estimates in the absence of direct measurements (B). IRBC volumes in (B) (dotted lines) were estimated from data in Park et al. [40] and Elliot et al. [23] by adding the cytosol volume from Park et al. [40] to the parasite volume from Elliot et al. [23]. [Hb] data in Panel E, from Park et al. [40], was obtained by dividing the Hb content of the cytosol by the water content of the cytosol after subtracting the volume occupied by the Hb molecules. The data was then normalized to the initial value of [Hb] used for the model simulations.