Table 2.

Effect of early and late type 2 pneumocyte products on alveolar macrophage response to hypoxia and reoxygenation.

	Media
Product	Control Media	Early T2P Mediaa	Late T2P Mediaa
CINC (pg/mL +/− SD)
Normoxic Control	33 +/− 3	94 +/− 15b	257 +/− 60b
Hypoxia
with 15 minutes reoxygenation	205 +/− 20b	440 +/− 50	260 +/− 37 e
with 4 hours reoxygenation	725 +/− 137b	149 +/− 21c	327 +/− 70c, e
MCP-1 (pg/mL +/− SD)
Normoxic Control	148 +/− 5	424 +/− 48b	896 +/− 73b, e
Hypoxia
with 15 minutes reoxygenation	358 +/− 58 b	566 +/− 41	805 +/− 95e
with 4 hours reoxygenation	699 +/− 138 b	515 +/− 59 d	875 +/− 62d, e
MIP-1α (pg/mL +/− SD)
Normoxic Control	3908 +/−303	2291 +/−294b	2319 +/−371b, e
Hypoxia
with 15 minutes reoxygenation	11284 +/−959b	12257 +/−1608	6373 +/−675e
with 4 hours reoxygenation	16999 +/− 1031b	4801 +/−545 c	2271 +/−178 c, e

^aCytokine content corrected for baseline content in media;

^bp<0.01 compared with normoxic controls;

^cp<0.01 compared with control media, comparable hypoxia/reoxygenation state;

^dp<0.01 compared with control media, comparable hypoxia/reoxygenation state;

^ep<0.01 compared with early media, comparable hypoxia/reoxygenation state; MIP-1α=macrophage inflammatory protein 1α CINC=cytokine-induced neutrophil chemoattractant; MCP-1=monocyte chemoattractant protein-1; AM=alveolar macrophage.

N=36 for each media/hypoxia-reoxygenation condition