Table 1.

In vivo effects of DFP on hippocampal ChE, FAAH, MAGL and CB1 receptor binding.

Treatmenta	ChEb	FAAHc	MAGLd	CB1e
Vehicle	78.1 ± 3.4 (100)	0.72 ± 0.02 (100)	1.10 ± 0.07 (100)	0.14 ± 0.01 (100)
DFP	8.7 ± 0.6 (11)*	0.42 ± 0.03 (58)*	1.08 ± 0.14 (98)	0.13 ± 0.01 (93)

^aRats (n=5/treatment group) were treated with either peanut oil (1 ml/kg, sc) or DFP in peanut oil (2.5 mg/kg) and sacrificed 24 hours later. Both sides of the hippocampus were dissected and frozen separately until assay. An asterisk indicates a significant difference between control and DFP-treated tissues. Values in parentheses represent percent of control.

^bCholinesterase activity is reported as nmol acetylcholine hydrolyzed/min˙mg protein (mean ± SE).

^cFAAH activity is reported as nmol anadamide hydrolyzed/min˙mg protein (mean ± SE).

^dMAGL activity is reported as nmol 2-oleoyl glycerol hydrolyzed/min˙mg protein (mean ± SE).

^eCB1 receptor binding data are presented as pmol [³H]CP 55,940 bound/mg protein ± SE.