Table 1.
Genes linked to the ECM maintenance and angiogenesis: HT-MT/HT-siRNA, the ratio of gene expression in HT-MT cells versus HT-siRNA cells (P < 0.01)
| Accession | Gene | HT-MT/HT-siRNA | |
|---|---|---|---|
| 1 | NM_022475 | Hedgehog interacting protein (HHIP) | 7.4 |
| 2 | NM_005328 | Hyaluronan synthase 2 (HAS2) | 7.1 |
| 3 | NM_012098 | Angiopoietin-like 2 (ANGPTL2) | 7.1 |
| 4 | NM_001845 | Collagen, type IV, alpha 1 (COL4A1) | 7.0 |
| 5 | NM_000362 | TIMP metallopeptidase inhibitor 3 (TIMP3) | 6.5 |
| 6 | NM_004004 | Gap junction protein, beta 2, 26kDa (GJB2) | 6.3 |
| 7 | NM_000093 | Collagen, type V, alpha 1 (COL5A1) | 3.9 |
| 8 | NM_014391 | Ankyrin repeat domain 1 (cardiac muscle) (ANKRD1) | 3.8 |
| 9 | NM_182943 | Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) | 3.5 |
| 10 | NM_033140 | Caldesmon 1 (CALD1) | 3.5 |
| 11 | NM_004105 | EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) | 3.4 |
| 12 | NM_002391 | Midkine (neurite growth-promoting factor 2) (MDK) | 3.4 |
| 13 | NM_032048 | Elastin microfibril interfacer 2 (EMILIN2) | 3.4 |
| 16 | NM_002290 | Laminin, alpha 4 (LAMA4) | 3.4 |
| 15 | NM_032603 | Lysyl oxidase-like 3 (LOXL3) | 3.3 |
| 16 | NM_002571 |
Progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein) (PAEP) |
3.3 |
| 17 | NM_130445 | Collagen, type XVIII, alpha 1 (COL18A1) | 3.1 |
| 18 | NM_054034 | Fibronectin 1 (FN1) | 3.0 |
| 19 | NM_002291 | Laminin, beta 1 (LAMB1) | 2.7 |
| 20 | NM_018837 | Sulfatase 2 (SULF2) | 2.7 |
| 21 | NM_001530 |
Hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HIF-1α) |
2.7 |
| 22 | NM_080591 |
Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (PTGS1) |
2.6 |
| 23 | NM_001235 |
Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) (SERPINH1) |
2.3 |
| 24 | NM_022356 | Leucine proline-enriched proteoglycan (leprecan) 1 (LEPRE1) | 2.3 |
| 25 | NM_030583 | Matrilin 2 (MATN2) | 2.3 |
| 26 | NM_015103 | Plexin D1 (PLXND1) | 2.3 |
| 27 | NM_014918 | Carbohydrate (chondroitin) synthase 1 (CHSY1) | 2.2 |
| 28 | NM_001849 | Collagen, type VI, alpha 2 (COL6A2) | 2.2 |
| 29 | NM_014584 | ERO1-like (S. cerevisiae) (ERO1L) | 2.2 |
| 30 | NM_002546 |
Tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) (TNFRSF11B) |
2.2 |
| 31 | NM_000176 |
Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1) |
2.1 |
| 32 | NM_001848. | Collagen, type VI, alpha 1 (COL6A1) | 2.0 |
| 33 | NM_001846 | Collagen, type IV, alpha 2 (COL4A2) | 2.0 |