Biomechanical and biochemical properties of IGF-I treated constructs in phase I. All IGF-I treatments, except 10 ng/ml continuous, significantly increased (a) aggregate modulus with no effect on (b) Young’s modulus. Likewise, all IGF-I treatments, except 10 ng/ml continuous, significantly increased (c) GAG/WW with no effect on (d) collagen/WW. Columns and error bars represent means and standard deviations. Groups denoted by different letters are significantly different (p<0.05).