Table 3.
Biodistribution of 111In-1 in PC-3 Tumor Bearing SCID Mice (n = 5).a
Organ/Tissue | 0.25-hr PI | 0. 5-hr PI | 1-hr PI | 4-hr PI |
---|---|---|---|---|
Bladder | 14.09 ± 21.1 | 7.03 ± 8.68 | 1.67 ± 1.06 | 0.26 ± 0.14 |
Heart | 1.85 ± 0.27 | 1.00 ± 0.30 | 0.16 ± 0.06 | 0.03 ± 0.02 |
Lung | 4.45 ± 0.82 | 3.56 ± 1.72 | 1.78 ± 1.64 | 1.48 ± 2.54 |
Liver | 2.14 ± 0.14 | 0.88 ± 0.20 | 0.27 ± 0.07 | 0.12±0.02 |
Kidneys | 11.84 ± 1.97 | 5.88 ± 1.91 | 3.06 ± 0.92 | 2.24±1.02 |
Spleen | 0.98 ± 0.37 | 0.59 ± 0.27 | 0.15 ± 0.08 | 0.06 ± 0.02 |
Stomach | 1.91 ± 0.29 | 1.17 ± 0.37 | 0.34 ± 0.07 | 0.05 ± 0.03 |
S. Intestine | 3.41 ± 0.54 | 1.46 ± 0.35 | 0.62 ± 0.19 | 0.18 ± 0.11 |
L. Intestine | 1.64 ± 0.29 | 0.59 ± 0.07 | 0.54 ± 0.68 | 0.88 ± 0.39 |
Muscle | 1.00 ± 0.10 | 0.40 ± 0.13 | 0.07 ± 0.04 | 0.02 ± 0.01 |
Bone | 1.21 ± 0.42 | 0.78 ± 0.40 | 0.08 ± 0.02 | 0.05 ± 0.07 |
Brain | 0.17 ± 0.06 | 0.12 ± 0.04 | 0.02 ± 0.01 | 0.00 ± 0.00 |
Pancreas | 14.88 ± 1.86 | 3.99 ± 0.49 | 0.96 ± 0.18 | 0.41 ± 0.14 |
Tumor#1 | 7.33 ± 1.18 | 5.41 ± 1.98 | 3.91 ± 0.46 | 2.02 ± 0.34 |
Tumor#2 | 6.47 ± 0.82 | 6.11 ± 1.04 | 3.52 ± 0.70 | 2.29 ± 0.36 |
Blood | 4.28 ± 0.59 | 1.85 ± 0.47 | 0.33 ± 0.15 | 0.02 ± 0.02 |
Carcass | 2.26 ± 0.34 | 1.16 ± 0.41 | 0.39 ± 0.38 | 0.05 ± 0.03 |
Excretion (% ID ± SD) | 40.86 ± 4.60 | 68.70 ± 7.55 | 89.15 ± 7.11 | 96.16 ± 1.06 |
Tumors | 6.90 ± 1.06 | 5.76 ± 1.54 | 3.72 ± 0.60 | 2.15 ± 0.36 |
All data, except excretion, are presented as an average % ID/g ± SD.