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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Cell Metab. 2009 Jan 15;9(2):152–164. doi: 10.1016/j.cmet.2008.12.012

Figure 7. Intestinal HIF-2 activates iron uptake into the small intestine.

Figure 7

(A) Under iron-replete conditions basal iron absorption and export maintain iron homeostasis. Iron export is inhibited through high basal expression of hepcidin and hepcidin-mediated internalization and degradation of FPN. Iron uptake is limited due to decreased expression of absorptive genes. (B) Under iron-deficient conditions, decreased hepcidin expression stabilizes FPN expression resulting in increased iron export. HIF-2α activates iron absorptive genes leading to increased iron uptake into the intestine.