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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Neuropharmacology. 2008 Jun 18;55(5):755–762. doi: 10.1016/j.neuropharm.2008.06.017

Fig. 1.

Fig. 1

Effect of in vivo SNC80 on amphetamine-mediated dopamine efflux from striatal tissue. Striatal preparations from either vehicle or 10 mg/kg SNC80 treated rats (s.c.) were perfused with a. 3 µM, b. 10 µM, c. 30 µM, d. 100 µM or e. 1 mM amphetamine sulfate for 5 min at fraction 7 as indicated by the line labeled AMPH. Fractions were collected at 5 min intervals for an additional 40 min. Dopamine content of the fractions was measured by HPLC-electrochemical detection as described in the Methods, and reported as pmol of dopamine per mg wet weight ± S.E.M (n = 4 in duplicate). f. The concentration-response curve of amphetamine-mediated dopamine efflux was plotted using AUC values obtained from graphs a.–e. Statistical significance was determined by two-way ANOVA with Bonferroni multiple comparison analysis. ***p < 0.001 compared to vehicle treated animals.