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. 2009 Apr 2;4(4):e5143. doi: 10.1371/journal.pone.0005143

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Chen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) voltage-dependent activation curves, and B) normalized activation curves. Curves were fitted using a Boltzmann function. V_h for KCNQ1 = −30.3±1.0 mV, KCNQ1/KCNE1 = 9.5±4.2 mV, KCNQ1/KCNE1-D76N = 43.5±3.0 mV, KCNQ1/KCNE1-Δ70 = 71.5±7.0 mV. n = 6, p<0.001 for both mutants compared to wild-type KCNE1.