Table 3. Cross-species comparison of domain-domain interactions from eight model organisms.
| Species | HUMAN | MOUSE | DROME | CAEEL | YEAST | PLAF7 | ARATH | ECOLI |
| HUMAN | 3759 | 4139 | 1672 | 5682 | 515 | 669 | 1389 | |
| MOUSE | 0.91 | 1603 | 803 | 1230 | 189 | 284 | 215 | |
| DROME | 0.64 | 0.52 | 1254 | 2210 | 338 | 387 | 363 | |
| CAEEL | 0.73 | 0.47 | 0.62 | 1120 | 217 | 253 | 285 | |
| YEAST | 0.46 | 0.34 | 0.39 | 0.51 | 577 | 662 | 1893 | |
| PLAF7 | 0.61 | 0.26 | 0.42 | 0.32 | 0.68 | 85 | 207 | |
| ARATH | 0.53 | 0.27 | 0.34 | 0.28 | 0.53 | 0.16 | 233 | |
| ECOLI | 0.16 | 0.07 | 0.08 | 0.14 | 0.24 | 0.25 | 0.20 |
HUMAN-Homo sapiens; MOUSE-Mus musculus; DROME-Drosophila melanogaster; CAEEL-Caenorhabditis elegans; YEAST-Saccharomyces cerevisiae; PLAF7-Plasmodium falciparum; ARATH-Arabidopsis thaliana; ECOLI-Escherichia coli. The upper diagonal shows the number of overlapping DDIs between specific pairs of species. Values in the lower diagonal represent DDI conservation similarity between specific pairs of species.