Table 4. Top five predicted DDIs that are conserved in multiple species, sorted by the number of species conserved.

sps#	Domain-1	Name	Domain-2	Name	Species	Score
8	IPR009057	Homeodomain_like	IPR009057	Homeodomain_like	HMDCYPAE	25.7
8	IPR000719	Prot_kinase_core	IPR001650	DNA/RNA_helicase_C	HMDCYPAE	13.5
8	IPR000719	Prot_kinase_core	IPR003593	AAA+_ATPase_core	HMDCYPAE	13.3
8	IPR003593	AAA+_ATPase_core	IPR003593	AAA+_ATPase_core	HMDCYPAE	11.7
8	IPR012335	Thioredoxin_fold	IPR012335	Thioredoxin_fold	HMDCYPAE	10.5
7	IPR001353	Proteasome_A_B	IPR001353	Proteasome_A_B	HMDCYAE	35.3
7	IPR012287	Homeodomain-rel	IPR012287	Homeodomain-rel	HMDCYAE	31.1
7	IPR004045	GST_N	IPR010987	GST_C_like	HMDCYAE	23.4
7	IPR000719	Prot_kinase_core	IPR003527	MAP_kin	HMDCYPA	22.9
7	IPR004045	GST_N	IPR004045	GST_N	HMDCYAE	20.6
6	IPR004827	TF_bZIP	IPR011700	bZIP_2	HMDCYA	37.4
6	IPR000426	Proteasome_alpha	IPR001353	Proteasome_A_B	HMDCYA	36.9
6	IPR001356	Homeobox	IPR012287	Homeodomain-rel	HMDCYA	36.6
6	IPR001092	HLH_basic	IPR011598	HLH_DNA_bd	HMDCYA	30.5
6	IPR013088	Znf_NHR/GATA	IPR013088	Znf_NHR/GATA	HMDCYE	29.9
5	IPR000243	Pept_T1A_subB	IPR001353	Proteasome_A_B	HMCYA	36.3
5	IPR008331	Ferritin_Dps	IPR008331	Ferritin_Dps	HMDCE	32.5
5	IPR001114	AdlSucc_Synth	IPR001114	AdlSucc_Synth	HMYAE	31.8
5	IPR001163	LSM_snRNP_core	IPR010920	LSM_related_core	HMDCY	31.6
5	IPR009078	Ferritin/RR_like	IPR012347	Ferritin_rel	HMDCE	29.6
4	IPR008946	Nucl_hrmn_rcpt_lig_bd	IPR013088	Znf_NHR/GATA	HMDC	38.4
4	IPR000793	ATPase_a_b_C	IPR004100	ATPase_a_b_N	HYAE	37.3
4	IPR007860	MutS_II	IPR007861	MutS_IV	HCYE	37.1
4	IPR001628	Znf_hrmn_rcpt	IPR008946	Nucl_hrmn_rcpt_lig_bd	HMDC	36.7
4	IPR011261	RNAP_dimerisation	IPR11262	RNAP_insert	HDYE	36.4
3	IPR002398	Pept_C14_p45	IPR011600	Pept_C14_cat	HMD	37.2
3	IPR009025	RNA_pol_RBP11-like	IPR011261	RNAP_dimersation	HDY	36.5
3	IPR013506	Topo_IIA_B_2	IPR013760	Topo_IIA_cen	HYE	36.0
3	IPR009025	RNA_pol_RBP11-like	IPR011262	RNAP_insert	HDY	35.5
3	IPR002205	Topo_IIA_A/C	IPR013757	Topo_IIA_A_a	HYE	35.4
2	IPR002314	AA-tRNA-synt_IIb	IPR015805	His-tRNA_synth	HE	37.4
2	IPR000971	Globin_subset	IPR002337	Haemoglobin_b	HM	34.6
2	IPR001217	STAT	IPR013800	STAT_alpha	HC	34.5
2	IPR009056	Cyt_c_monohaem	IPR012282	Cytochrome_c_R	HY	34.5
2	IPR007120	RNA_pol_Rpb2_6	IPR007644	RNApol_bsu_protrusn	HY	34.3
1	IPR002100	TF_MADSbox	IPR002487	TF_Kbox	A	38.4
1	IPR004516	His-tRNA_synth_IIA	IPR015805	His-tRNA_synth	E	38.3
1	IPR002104	Integrase_cat-core phage	IPR013762	Integrase-like_cat-core_phage	E	37.6
1	IPR007627	RNA_pol_sigma70_r2	IPR014284	RNA_pol_sigma-70	E	36.4
1	IPR001576	Phosphoglycerate_kinase	IPR015824	Phosphoglycerate_kinase-N	Y	35.9

H-human, M-mouse, D-Drosophila, C-C.elegans, Y-yeast, P-Plasmodium, A-Arabidopsis, E-E. coli.