Table 4. Top five predicted DDIs that are conserved in multiple species, sorted by the number of species conserved.
sps# | Domain-1 | Name | Domain-2 | Name | Species | Score |
8 | IPR009057 | Homeodomain_like | IPR009057 | Homeodomain_like | HMDCYPAE | 25.7 |
8 | IPR000719 | Prot_kinase_core | IPR001650 | DNA/RNA_helicase_C | HMDCYPAE | 13.5 |
8 | IPR000719 | Prot_kinase_core | IPR003593 | AAA+_ATPase_core | HMDCYPAE | 13.3 |
8 | IPR003593 | AAA+_ATPase_core | IPR003593 | AAA+_ATPase_core | HMDCYPAE | 11.7 |
8 | IPR012335 | Thioredoxin_fold | IPR012335 | Thioredoxin_fold | HMDCYPAE | 10.5 |
7 | IPR001353 | Proteasome_A_B | IPR001353 | Proteasome_A_B | HMDCYAE | 35.3 |
7 | IPR012287 | Homeodomain-rel | IPR012287 | Homeodomain-rel | HMDCYAE | 31.1 |
7 | IPR004045 | GST_N | IPR010987 | GST_C_like | HMDCYAE | 23.4 |
7 | IPR000719 | Prot_kinase_core | IPR003527 | MAP_kin | HMDCYPA | 22.9 |
7 | IPR004045 | GST_N | IPR004045 | GST_N | HMDCYAE | 20.6 |
6 | IPR004827 | TF_bZIP | IPR011700 | bZIP_2 | HMDCYA | 37.4 |
6 | IPR000426 | Proteasome_alpha | IPR001353 | Proteasome_A_B | HMDCYA | 36.9 |
6 | IPR001356 | Homeobox | IPR012287 | Homeodomain-rel | HMDCYA | 36.6 |
6 | IPR001092 | HLH_basic | IPR011598 | HLH_DNA_bd | HMDCYA | 30.5 |
6 | IPR013088 | Znf_NHR/GATA | IPR013088 | Znf_NHR/GATA | HMDCYE | 29.9 |
5 | IPR000243 | Pept_T1A_subB | IPR001353 | Proteasome_A_B | HMCYA | 36.3 |
5 | IPR008331 | Ferritin_Dps | IPR008331 | Ferritin_Dps | HMDCE | 32.5 |
5 | IPR001114 | AdlSucc_Synth | IPR001114 | AdlSucc_Synth | HMYAE | 31.8 |
5 | IPR001163 | LSM_snRNP_core | IPR010920 | LSM_related_core | HMDCY | 31.6 |
5 | IPR009078 | Ferritin/RR_like | IPR012347 | Ferritin_rel | HMDCE | 29.6 |
4 | IPR008946 | Nucl_hrmn_rcpt_lig_bd | IPR013088 | Znf_NHR/GATA | HMDC | 38.4 |
4 | IPR000793 | ATPase_a_b_C | IPR004100 | ATPase_a_b_N | HYAE | 37.3 |
4 | IPR007860 | MutS_II | IPR007861 | MutS_IV | HCYE | 37.1 |
4 | IPR001628 | Znf_hrmn_rcpt | IPR008946 | Nucl_hrmn_rcpt_lig_bd | HMDC | 36.7 |
4 | IPR011261 | RNAP_dimerisation | IPR11262 | RNAP_insert | HDYE | 36.4 |
3 | IPR002398 | Pept_C14_p45 | IPR011600 | Pept_C14_cat | HMD | 37.2 |
3 | IPR009025 | RNA_pol_RBP11-like | IPR011261 | RNAP_dimersation | HDY | 36.5 |
3 | IPR013506 | Topo_IIA_B_2 | IPR013760 | Topo_IIA_cen | HYE | 36.0 |
3 | IPR009025 | RNA_pol_RBP11-like | IPR011262 | RNAP_insert | HDY | 35.5 |
3 | IPR002205 | Topo_IIA_A/C | IPR013757 | Topo_IIA_A_a | HYE | 35.4 |
2 | IPR002314 | AA-tRNA-synt_IIb | IPR015805 | His-tRNA_synth | HE | 37.4 |
2 | IPR000971 | Globin_subset | IPR002337 | Haemoglobin_b | HM | 34.6 |
2 | IPR001217 | STAT | IPR013800 | STAT_alpha | HC | 34.5 |
2 | IPR009056 | Cyt_c_monohaem | IPR012282 | Cytochrome_c_R | HY | 34.5 |
2 | IPR007120 | RNA_pol_Rpb2_6 | IPR007644 | RNApol_bsu_protrusn | HY | 34.3 |
1 | IPR002100 | TF_MADSbox | IPR002487 | TF_Kbox | A | 38.4 |
1 | IPR004516 | His-tRNA_synth_IIA | IPR015805 | His-tRNA_synth | E | 38.3 |
1 | IPR002104 | Integrase_cat-core phage | IPR013762 | Integrase-like_cat-core_phage | E | 37.6 |
1 | IPR007627 | RNA_pol_sigma70_r2 | IPR014284 | RNA_pol_sigma-70 | E | 36.4 |
1 | IPR001576 | Phosphoglycerate_kinase | IPR015824 | Phosphoglycerate_kinase-N | Y | 35.9 |
H-human, M-mouse, D-Drosophila, C-C.elegans, Y-yeast, P-Plasmodium, A-Arabidopsis, E-E. coli.