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Conserved and divergent functions of PGRMC1 proteins in evolution. In unicellular organisms, Dap1 binds and activates the P450 protein Cyp51, promoting sterol synthesis and damage resistance. In mammals, PGRMC1 binds to multiple P450 proteins, suggesting additional functions in drug and hormone metabolism. PGRMC1 also binds to an unknown progesterone binding protein, to PAIR-BP1 and to Insig and SCAP.
