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. 2009 Apr 2;4(4):e5011. doi: 10.1371/journal.pone.0005011

Figure 6. Levels of CDKN1C expression predict the clinical outcome of breast cancer patients.

Figure 6

(A) Upregulation of EZH2 and downregulation of CDKN1C expression are shown in multiple cancer types with indicated P values by comparing the tumor (red) and the adjacent normal (blue) tissues. The data is extracted from Oncomine microarray database (www.oncomine.org). Breast cancer patients were ranked according to different levels of EZH2 or CDKN1C as described in Methods. (B) Kaplan-Meier survival plots of disease-free survival (DFS) from Stockholm cohort (Miller, et. al., GEO ID GSE3494). Patients with higher EZH2 or CDKN1C expression are highlighted in red, while patients with lower EZH2 or CDKN1C expression are highlighted in green. (C) Kaplan-Meier survival plots of disease-free survival (DFS) from Stockholm cohort. Patients with higher EZH2 but lower CDKN1C are highlighted in green, while patients with lower EZH2 but higher CDKN1C are highlighted in red.