Overview of the structure and comparison with other FadR-superfamily transcription factors. VanR-group members are shown at the top of the figure and FadR-group members are shown at the bottom of the figure. The PDB codes for the proteins shown are TM0439, 3fms; Rhodococcus sp. protein RO03477, 2hs5; Pseudomonas protein PS5454, 3c7j; FadR, 1e2x; CGL2915, 2di3. The red and pink colors denote the DNA-binding domain, with the HTH motif highlighted in red. The FCD domain has been colored with a spectrum from blue to red, with the α0 helix of the FadR subfamily highlighted in magenta. The grey chain represents the second monomer in the dimer.