TABLE 1.
Clinical and biochemical profiles of patients among subgroups
| Patient profile | Ferritin concentration (μg/L)
|
||||
|---|---|---|---|---|---|
| 300 to 400 | 401 to 500 | 501 to 600 | 601 to 1000 | Greater than 1000 | |
| Men, % | 77 | 75 | 88 | 75 | 77 |
| Women, % | 23 | 25 | 12 | 25 | 23 |
| Mean age, years | 49.5 | 52.3 | 51.6 | 55.3 | 53.5 |
| Liver biopsy, n | 12 | 17 | 7 | 35 | 75 |
| Iron overload, % (ratio) | 8 (1/12) | 12 (2/17) | 43 (3/7) | 34 (12/35) | 45 (34/75) |
| Mean transferrin saturation, % | 36 | 42 | 39 | 49 | 59 |
| Hemochromatosis, % (ratio) | 28 (23/83) | 33 (29/89) | 29 (16/56) | 38 (51/135) | 42 (50/119) |
| C282Y homozygote, % (ratio) | 35 (8/23) | 57 (17/29) | 62.5 (10/16) | 69 (35/51) | 86 (43/50) |
| H63D homozygote, % (ratio) | 35 (8/23) | 21 (6/29) | 6 (1/16) | 12 (5/51) | 2 (1/50) |
| Compound heterozygote (C282Y/H63D), % (ratio) | 30 (7/23) | 21 (6/29) | 31 (5/16) | 20 (10/51) | 12 (6/50) |
Iron overload is defined as a liver iron concentration greater than 35 μmol/g (normal range 0 μmol/g to 35 μmol/g)