Table 3.
Overnight (2200-0759) FFA and GH levels, fasting (0759) glucose and insulin levels, AIR, SIMM, disposition index and glucose AUC during the IVGTT, and insulin MCR, p3, p2, SGMM, and Vg for treatments B (24-h fast with placebo) and C (24-h fast with acipimox)
| 24-h Fast + Placebo | 24-h Fast + Acipimox | P | |
|---|---|---|---|
| FFA AUC, *104 μmol/l*min) | 51.4 (45.2–57.5) | 40.0 (29.7–50.3) | 0.03 |
| Basal GH, ng/ml | 0.48 (0.07–0.90) | 5.45 (0.94–9.97) | 0.001 |
| Mean GH, ng/ml | 4.0 (1.7–6.3) | 27.2 (18.2–36.3) | <0.0001 |
| Maximal GH, ng/ml | 18.7 (9.5–27.9) | 127.1 (80.8–173.3) | <0.0001 |
| GH amplitude, ng/ml*min | 81.7 (48.5–114.9) | 432.3 (298.5–566.1) | <0.0001 |
| Fasting glucose, mmol/l | 3.2 (3.0–3.4) | 3.1 (2.9–3.3) | 0.4 |
| Fasting insulin, pmol/l | 12.1 (9.6–14.5) | 11.1 (7.3–14.9) | 0.6 |
| AIR, *102 pmol/l*min | 13.2 (9.1–17.3) | 15.9 (12.9–18.9) | 0.2 |
| SIMM, *10−4 min−1 per mU/l | 2.9 (2.1–3.7) | 4.5 (2.3–6.7) | 0.07 |
| Disposition index, *102 pmol/mU | 36.9 (22.0–51.8) | 60.5 (40.0–81.1) | 0.03 |
| Glucose AUC, mmol/l*min | 337.9 (257.8–418.0) | 357.3 (290.7–424.0) | 0.6 |
| Insulin MCR, l min−1 per kg | 0.06 (0.04–0.08) | 0.06 (0.05–0.08) | 0.9 |
| p3, *10−6 min−2 per mU/l | 8.9 (5.4–12.5) | 8.0 (0.5–15.6) | 0.2 |
| p2, *10−2 min−1 | 2.9 (2.2–3.5) | 1.3 (0.7–1.8) | <0.0001 |
| SGMM, *10−2 min−1 | 1.7 (1.6–1.9) | 1.7 (1.5–1.9) | 0.9 |
| Vg, l/kg | 0.21 (0.21–0.22) | 0.21 (0.20–0.22) | 0.7 |
Data are means (95% CI).