Table 1.
Small G Proteins identified in acinar cells
| Family | G Protein | Localization | Function | Refs. |
|---|---|---|---|---|
| Ras | Ras | PM | Growth | 20, 80 |
| Rap1 (A & B) | ZG, membrane | Exocytosis | 15, 96,100 | |
| RalA | ? | ? | 96 | |
| Rab | Rab1 | ER | ER-Golgi transport | 14, 96 |
| Rab2 | ER | ER-Golgi transport | 14, 96 | |
| Rab3D | ZG | Exocytosis | 11, 14, 86 | |
| Rab4 | Terminal web | Exocytosis, endocytosis | 87, 117, 129 | |
| Rab5 (A, B, & C) | ZG, endosomes | ?, Endocytosis | 14, 96 | |
| Rab6A | Golgi | Golgi transport | 15, 96 | |
| Rab7 | ? | ? | 96 | |
| Rab8A | ZG | Granule formation | 15, 29, 96 | |
| Rab10 | ? | ? | 96 | |
| Rab11 (A & B) | Apical pole | ? | 14, 15, 46, 96 | |
| Rab14 | ZG | Exocytosis? | 14, 15, 96 | |
| Rab18 | ? | ? | 96 | |
| Rab26 | ? | ? | 96, 120 | |
| Rab27B | ZG | Exocytosis | 13, 14, 15, 96 | |
| Rab35 | ? | ? | 96 | |
| Rho | RhoA | Cytoplasmic, membrane | Actin cytoskeleton, secretion | 3, 4, 62, 83 |
| RhoG | ? | ? | 96 | |
| Rac1 | Cytoplasmic, membrane | Actin cytoskeleton, secretion | 3, 4, 15, 96 | |
| Cdc42 | ? | ? | 4, 96 | |
| Arf | Arf4 | ? | ? | 96 |
Rab7, Rab10, Rab18, Rab35, Arf4, and RalA have been reported in mass spectrometry studies in which at least two unique peptides were identified. Abreviations: PM, plasma membrane; ZG, zymogen granule; ER, endoplasmic reticulum.