Table 2.
Regulators and effectors of small G Proteins in acinar cells
| G Protein | GEF | GAP | Effector |
|---|---|---|---|
| Ras | SOS | * | cRaf1 |
| Rap1 | Epac1 | Rap-GAP | * |
| CalDAG-GEFIII | |||
| Rab3D | Rab3-GEP | Rab3-GAP | Noc2 |
| GRAB | Slp1 | ||
| Myosin Vc | |||
| Rab27B | Rab3-GEP | * | Slp1 |
| Myosin Vc | |||
| RhoA | p115 Rho-GEF | p50 Rho-GAP | Rho kinase |
| LARG | p190 Rho-GAP-B | Src | |
| Rac1 | * | RICS | PAK2 |
GEF, guanine nucleotide exchange factor; GAP, guanine nucleotidase-activating protein.
*
Regulatory molecules have been identified in other cell types but not evaluated in acinar cells. References are included in the text.