Table 1.

Caspase activities and DNA fragmentation after diquat and galactosamine/endotoxin

	Controls	Diquat	Gal/ET
ALT, U/l	46±3	955±91*	3,867±158*
Caspase-3 activities, RFU·min−1·mg protein−1	23±2	23±1	59±4*
DNA fragmentation, %baseline	100±3	127±26	604±4*
TUNEL-positive cells, cells/15 HPF	6±1	35±4*	618±79*

Values are means ± SE of n = 6 animals per group. Fischer rats were treated with either saline (Controls), 0.15 mmol/kg diquat, or 500 mg/kg galactosamine/0.1 mg/kg endotoxin (Gal/ET) for 6 h. ALT, alanine aminotransferase; RFU, relative fluorescence unit; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling; HPF, high-power field.