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. 2009 Jan 8;296(3):G621–G631. doi: 10.1152/ajpgi.90567.2008

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Copyright © 2009, American Physiological Society

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Fig. 1. — Application of sulfated cholecystokinin (CCK-8s) in the dorsal vagal complex (DVC) induces a vagally mediated decrease in gastric tone. A: representative 50-μm-thick photomicrograph (top) of brain stem injection site with the region of injection circled and schematic representation (bottom) of effective injection areas (⧫) and injections without a response (□). AP, area postrema; NTS, nucleus tractus solitarii; DMV, dorsal motor nucleus of the vagus; CC, central canal; XII, hypoglossus. Bar: 250 μm. B: representative original polygraph records of gastric motility and tone from fasted animals after microinjection of PBS or 450 pmol of CCK-8s. C: original polygraph records from fasted animals after 4th ventricle application of 2 μl of PBS or CCK-8s demonstrating dose-dependent relaxation of the stomach. D: graphic summary of dose-dependent gastric relaxation induced by CCK-8s. *P < 0.05.