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. 2009 Jan 8;296(3):G621–G631. doi: 10.1152/ajpgi.90567.2008

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Fig. 2. — Gastroinhibition induced by centrally applied CCK-8s is vagally mediated. A: original trace from fasted animal in which posterior branch of gastric vagus was transected subdiaphragmatically before recording and suture ligature was loosely affixed around anterior vagus branch. Oblique lines indicate 5- to 10-min interval for recovery. After microinjection of PBS or 450 pmol of CCK-8s (top and middle, respectively) ligature was withdrawn, completing vagotomy (Vgtx). Gastric relaxation produced by subsequent application of CCK-8s (450 pmol) was abolished by vagotomy (bottom). B: graphic summary of gastric relaxation induced by CCK-8s microinjection before and after complete vagotomy. C: application of PBS or 15 nmol CCK-8s to floor of 4th ventricle (top and middle, respectively) produced results similar to that observed after microinjection. Vagotomy also abolished the response to 4th ventricle application of CCK-8s (15 nmol) (bottom). D: graphic summary of gastric relaxation induced by 4th ventricle CCK-8s before and after complete vagotomy. *P < 0.05.