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A: total IP3 production at rest (L0) and when stimulated with 25 μM carbachol. The IP3 levels were higher in the SM-B KO bladders both at rest and when activated by carbachol, P < 0.05. B: results for total IP production. There was no difference in the IP production in the absence of stimulation while carbachol (25 μM) caused an increase in the SM-B KO compared with the WT, P < 0.05.
