Fig. 8.

Appearance of TLOs is decreased with TNA treatment. CnAα^+/− mice were treated with vehicle or neutralizing TGF-β antibody from 16–24 wk of age and then TLO formation was examined in the kidney (A and B), intestine (C and D), liver (E and F), and lung (G and H). Data shown in A, C, E, and G are vehicle-treated mice and are representative of at least 10 mice. Data shown in B, D, F, and H are TNA-treated and are representative of at least 10 mice. Original magnification in A and B was ×40; C–H were ×10.