Effect of 20-HETE synthesis inhibition on kidney mass in a rat model of autosomal recessive polycystic kidney disease (ARPKD). HET-0016 (10 mg·kg−1·day−1), a specific inhibitor of 20-HETE synthesis, was administered daily to polycystic kidney (PCK) rats into the intraperitoneal space, and the animals were killed between postnatal days 56 and 63. The kidneys were harvested, fixed in plastic, and sectioned. Representative kidney sections from four different rats treated with either vehicle (A and C) or HET-0016 (B and D) are shown. Sections were stained with hematoxylin; n = 4 kidneys/group. Magnification ×20.