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Effect of postnatal age on resistance level pulmonary artery (PRA) responses to NG-nitro-l-arginine methyl ester (l-NAME). PRA from piglets aged 2 days (n = 16 PRA from 9 piglets), 5–7 days (n = 7 PRA from 7 piglets), and 12 days (n = 11 PRA from 7 piglets) were exposed to increasing concentrations (Conc) of l-NAME. At each concentration, l-NAME caused a greater constriction in PRA from 5- to 7-day- and 12-day-old piglets than in 2-day-old piglets. *P < 0.001, different from 2-day-old.
