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. 2008 Nov 26;296(3):L489–L499. doi: 10.1152/ajplung.90488.2008

Fig. 3.

Fig. 3.

Hypoxic HPASMC proliferation is mediated by NOX4. A: cells were treated with DPI (2.0 μM) before exposure to hypoxia for 72 h. Counts were performed before and after hypoxia (1% O2) and are expressed as total number of cells ×103. Each condition represents the mean of 4 samples ± SD. *P < 0.001, 1% O2 vs. 21% O2 at 72 h. †P < 0.001, 1% O2 vs. 1% O2 + DPI at 72 h. B: HPASMC were transfected with small interfering RNA (siRNA) oligomer for NOX4 (siNOX4) before exposure to hypoxia for 72 h. Counts are expressed in total number of cells ×103. Each condition represents the mean of 4 samples ± SD. *P < 0.001, 1% O2 vs. 21% O2. †P < 0.001, 1% O2 control cells vs. 1% O2 + siNOX4.