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Active developed force over 24 h of high-loaded culture cardiac trabeculae in the absence (•, n = 9) and presence (○, n = 6–8) of selective pharmacological antagonists. PD-145065 (A) is a nonselective endothelin receptor antagonist, BQ-123 (B) is a specific endothelin A receptor antagonist, losartan (C) and telmisartan (D) are angiotensin II receptor antagonists, and SB-431542 (E) is a selective inhibitor of activin receptor-like kinase receptors.
