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The range of regulation of spontaneous (Spont.) AP firing rate by Pup substantially shrinks as gCaL (A) or gIf (B) increases. The curves illustrate the results of our model sensitivity analysis (basal model) for spontaneous AP rate change, with Pup varying from its basal value of 12 mM/s. The respective conductance values are shown at the curves, with 2× and 3× representing their multiples.
