Table 2.
Basic AP characteristics of our basal firing model (in bold) are similar to those of some previous SANC models and within experimental data
| Characteristics | Noble and Noble (49) Central SANC Model | Zhang et al. (73) Central SANC Model | Demir et al. (10) SANC Model | Kurata et al. (27) Central SANC Model | Present Model of Central SANC | The Range of Experimental Values |
|---|---|---|---|---|---|---|
| MDP, mV | −61 | −58 | −61 | −59 | −62.7 | −66.2 to −51.9 |
| APA, mV | 84 | 79 | 96 | 75 | 75.9 | 66–78 |
| CL, ms (AP rate, Hz) | 263 (3.8) | 327 (3.06) | 263 (3.8) | 307.5 (3.26) | 333 (3) | 247–389 (2.6–4.1 Hz) |
| APD50, ms | 70 | 139 | 86 | 107 | 101 | 72.7–111 |
| dV/dtmax, V/s | 4.7 | 2.7 | 9.6 | 6.4 | 4.8 | 4.8–27 |
All data for prior models were taken from Table 3 in Ref. 71. The ranges of experimental values were evaluated based on data in Table 1 in Ref. 27 (compiled from 12 studies that used physiological temperatures). MDP, maximum diastolic potential; APA, action potential (AP) amplitude; APD50, AP duration at its half amplitude; dV/dtmax, the maximum rate of rise of membrane potential during AP upstroke; CL, cycle length.