Table 2.
Effect of physical activity and regulated energy on intratumoral vascular density
| Vessel Size Category, μm2 | Unit of Measure* | Treatment Group |
||
|---|---|---|---|---|
| SC | RE | PA | ||
| Cat. 1: ≤10 | Count | 14.4±25.3 (4.0, 7.0, 10.0) | 15.4±18.5 (3.0, 5.0, 24.0) | 10.8±12.1 (2.0, 5.0, 15.0) |
| Cat. 2: >10 and ≤25 | Count | 33.6±20.1 (22.0, 35.0, 42.0) | 36.8±26.8 (16.0, 33.0, 39.0) | 31.0±22.2 (7.0, 30.0, 51.0) |
| Cat. 3: >25 and ≤50 | Count | 33.1±13.73 (31.0, 38.0, 42.0) | 24.0±13.4 (11.0, 26.0, 29.0) | 18.7±8.2 (9.0, 19.0, 25.0) |
| Cat. 4: >50 and ≤75 | Count | 12.3±5.1 (11.0, 14.0, 17.0) | 7.8±6.6 (3.0, 7.0, 10.0) | 6.6±5.9 (4.0, 5.0, 8.0) |
| Cat. 5: >75 | Count | 20.8±14.2 (12.0, 17.0, 28.0) | 13.1±8.8 (5.0, 15.0, 17.0) | 12.4±8.8 (3.0, 14.0, 21.0) |
| Total | Count | 114.2±59.8 (87.0, 118.0, 125.0) | 97.1±52.7 (63.0, 88.0, 125.0) | 79.4±39.5 (69.0, 75.0, 89.0) |
| Cat. 1: ≤10 | Area | 99.3±167.0 (30.6, 51.9, 73.9) | 107.8±121.6 (28.3, 34.0, 176.1) | 80.4±83.1 (14.3, 44.3, 119.3) |
| Cat. 2: >10 and ≤25 | Area | 591.4±331.3 (413.0, 667.2, 737.1) | 610.8±418.8 (318.6, 538.2, 667.2) | 502.1±351.1 (129.4, 443.9, 845.5) |
| Cat. 3: >25 and ≤50 | Area | 1,164.0±491.9 (1,021.3, 1,442.1, 1672.6) | 846.3±475.7 (391.2, 866.3, 1,129.6) | 659.6±293.1 (325.6, 683.4, 894.3) |
| Cat. 4: >50 and ≤75 | Area | 743.7±313.6 (641.5, 858.1, 1,017.8) | 466.5±402.5 (179.8, 410.9, 585.6) | 398.8±355.4 (241.5, 311.6, 485.1) |
| Cat. 5: >75 | Area | 4,623.2±3,650.4 (1,332.8, 3,741.3, 10,345.3) | 3,763.0±3,606.3 (955.1, 2,687.5, 6,705.3) | 3,164.7±3,011.9 (403.4, 2,817.8, 4,588.3) |
| Total | Area | 7,221.6±4,184.9 (4,700.3, 7,030.0, 10,589.8) | 5,794.3±4,369.4 (1,725.0, 4,076.0, 9,872.5) | 4,805.6±3,307.4 (2,030.9, 4,172.2, 6,848.3) |
Values are means ± SD.
*
Count data are average number of blood vessels/mm2; area data are average area in μm2/mm2. Nos. in parentheses are (25th percentile, median, 75th percentile); n = 9 carcinomas in each treatment group. SC, sedentary control group; RE, regulated energy group; PA, physically active group; Cat. 1–Cat. 5, categories 1–5. Total density of intratumoral blood vessels was reduced by PA (P = 0.03) or RE (P = 0.09). The reduction was significant for vessel size categories above 25 μm2, P < 0.05.