Table 4.

Potency of amiloride analogs for Reissner's membrane

Drug	IC50, μM (pIC50, M)	*IC50, μM (pIC50, M)	Hill Coeff
Amiloride
Control	0.75 (−6.12±0.08)	1.03 (−5.99±0.11)	1.39
Dex	0.68 (−6.17±0.14)	0.89 (−6.05±0.06)	0.92
Benzamil
Control	0.10 (−7.01±0.16)	0.20 (−6.68±0.25)	0.90
Dex	0.09 (−7.05±0.10)	0.10 (−7.01±0.11)	1.00
EIPA
Control	20.8 (−4.68±0.24)		0.79
Dex	47.5 (−4.32±0.44)		0.73

Values are means ± SE (n = 5 for each drug). IC₅₀, concentration required to produce half-maximal current density inhibition. Cont, control incubation without dexamethasone; Dex, incubation with dexamethasone.

^*IC₅₀ from fit to Hill equation with residual current during maximal inhibition by drug (I_offset) = 0.