Table 2.
Amino acid heterogeneity of V3 region of HIV-1 proviral quasispecies harboured by monocytes (CD36) and T lymphocytes (CD26) and of plasma virions replicating in the two cell types after HAART interruption.
| Patient | Sample type | N. of unique variants* | Diversity** | Complexity*** | |
| Pt.1 | Provirus | CD36 | 161 | 0.0795 ± 0.0005 | 0.3798 |
| CD26 | 226 | 0.0197 ± 0.0001 | 0.2119 | ||
| Pt.2 | Provirus | CD36 | 231 | 0.1446 ± 0.0005 | 0.3620 |
| CD26 | 59 | 0.0031 ± 0.0001 | 0.0919 | ||
| Pt.3 | Provirus | CD36 | 46 | 0.0508 ± 0.0003 | 0.3042 |
| CD26 | 3 | 0.0084 ± 0.0002 | 0.0738 | ||
| Virus | CD36 | 26 | 0.0428 ± 0.0010 | 0.2979 | |
| CD26 | 158 | 0.0298 ± 0.0003 | 0.3293 | ||
| Pt.4 | Provirus | CD36 | 76 | 0.0226 ± 0.0007 | 0.1127 |
| CD26 | 14 | 0.0457 ± 0.0003 | 0.1755 | ||
| Virus | CD36 | 15 | 0.0113 ± 0.0002 | 0.1138 | |
| CD26 | 41 | 0.0208 ± 0.0002 | 0.1222 | ||
| Pt.5 | Provirus | CD36 | 157 | 0.0585 ± 0.0003 | 0.2756 |
| CD26 | 120 | 0.0411 ± 0.0004 | 0.4233 | ||
| Virus | CD36 | 305 | 0.0728 ± 0.0005 | 0.3664 | |
| CD26 | 38 | 0.0042 ± 0.0001 | 0.0870 | ||
Sequences obtained by ultra-deep pyrosequencing were filtered through the correction algorithm and amino acid sequences obtained were analyzed to establish diversity and complexity, as described in the Materials and Methods section.
* Number of unique sequences obtained after dereplication
** Diversity: p distance ± SEM
*** Complexity: normalized Shannon entropy